Scanning electrochemical microscopy (SECM) is an innovative device used to study the electrochemical activity of various surfaces, including enzymatic biosensors. SECM is based on electrochemical measurements performed with a spatially movable ultramicroelectrode (UME). In conventional SECM experiments, the UME is switched on in an electrochemical cell as a working electrode, and the current flowing through it depends on the concentration of electrically active compounds at the microelectrode positioning site. In this way, the concentration of chemicals formed or consumed during the reaction at various surface locations can be determined. For the first time, the kinetics of electron transfer on non-conducting enzyme-modified surfaces was studied in the Allen Bard group using the feedback mode. Since then, SECM has been applied in many biosensor studies.

Why you need SECM (2.0)